Molecular Phylogenetic Analysis of Canine Parvovirus Strains Circulating in Iran

Background and aims: canine parvovirus type 2 (cpv 2) suddenly appeared as a pathogen in dogs in the late 1970s, causing a severe and often fatal gastrointestinal illness. the original cpv 2 was replaced by three types of variants, cpv 2a, cpv 2b and cpv 2c, which to date have achieved global distribution in varying proportions. all previous studies in iran were based on partial vp2 gene sequence. the aim of this study was to provide genome analysis to describe cpv strains collected in tehran, iran. materials and methods: rectal swab samples were collected in 2019 and tested using serological methods. out of forty positive samples, nine samples were selected for further analysis using various molecular methods. results: the results revealed a high prevalence of cpv-2a, cpv-2b and cpv2-c variants. phylogenetic analysis showed that in tehran the cpv 2b, cpv 2a and cpv-2 c strains were related to a cluster of specimens. thus, the results suggested that cpv 2 sequences is not the results potential recombination events here. conclusion: continuous monitoring and molecular characterization of cpv2 samples is necessary not only to identify possible genetic and antigenic changes that may interfere with the effectiveness of vaccines, but also to better understand the mechanisms of cpv 2 evolution in iran.