Evaluation of Epstein - Barr virus Frequency in Paraffin- Embedded Tissues of Hodgkin and Non-Hodgkin Lymphoma Patients in Kerman Province

Background and aims: ebv infection usually occurs in humans and is very common. seroepidemiological surveys show that over 95% of adults worldwide are faced with ebv virus. the epstein-barr virus causes infectious mononucleosis and its association with a number of human cancers, including hodgkin's lymphoma, non-hodgkin lymphoma (especially lymphoma bl), nasopharyngeal carcinoma, gastric carcinoma and breast cancer has been established. materials and methods: this study was conducted cross-sectional. this study was designed to determine the presence of the epstein-barr virus genome in tissue samples of patients with hodgkin lymphoma and non-hodgkins. in this study, 40 samples of patients with non- hodgkin's lymphoma and hodgkin's disease, while had been kept in archives of the shahid bahonar hospital, afzalipour hospital and payambar-e-azam hospital of kerman were examined by real-time pcr technique. the data collected by spss software and chi-square test were analyzed. results: the prevalence of ebv in patients in this study was 5/27% of the 40 sample, of which 20 cases were of hodgkin lymphoma and 20 cases were of non-hodgkin lymphoma. no significant correlation was found between the prevalence of ebv in hodgkin and non- hodgkin lymphoma. there was also no correlation between men and women of different ages for the presence of ebv dna in patients samples (p>0.05). conclusions: ebv dna associated with the tumor could be detected by molecular methods which are useful for the diagnosis of ebv-associated diseases, also biological factors such as age, sex, health status, social and economic factors in the pathogenesis of ebv and its relationship to lymphoma was not observed.