Sero-prevalence of Herpes Simplex and Epstein Barr Viruses in HIV positive patients in Tehran

Background and aims: the burden of hiv infection and disease continues to be a major global public health concern all over the world. this study was conducted to measure igg antibody against ebv viral capsid antigen (ebv-vca igg), herpes simplex type1, and 2 to determine the seroprevalence of this infection in hiv-positive population. materials and methods: a cross-sectional study between march and august 2016 was conducted in keyvan virology laboratory enrolling 84 hiv-positive patients with different age and sexes. enzyme-linked immunosorbent assay (elisa) was used for determination of igg antibody against herpes simplex type1, type 2 viruses, ebv and hiv viral loaddetected in plasma by real time-pcr in obtained samples from hiv-positive patients. results: the overall seroprevalence was 66.7% for anti-hsv-1 igg, 14.3% for anti-hsv-2 igg, and 94% for anti-ebv igg. there was no significant difference between the sex groups for hsv-1 and -2, ebv and hiv load and their igg level. this study also showed a correlation between the age, and the antibody titers only for hsv-1 and -2 with p=0.030 and p= 0.024, respectively. conclusions: in our study, the seroprevalence of ebv and hsv-1 igg were higher in hivpositive patients. it can be derived that hsv-2 virus is not major coinfection in iran, thus requires less attention than others, but annually monitoring needs for proper health care programs.