correlation between polymorphism of -56 snp (t/c) interferon-γ receptor 1 gene and chronic hbv infection

Background and aims: chronic hbv infection is one of the most common viral infections in worldwide which many factors such as genetic factors are involved in pathogenesis of disease. gamma interferon (ifn-γ) and its receptor (infgr) play a critical role in the immune response to hbv infection. single nucleotide polymorphisms (snps) are effective on level of gene expression, the aim of this study is explore the effect of -56t/c(snp) located in promoter of gamma interferon receptor1 (infgr1)gene on chronic hbv infection. methods: genomic dna from peripheral blood samples of 150 chronically hbv infected patients and 150 healthy controls was extracted by phenol-chloroform method and dna analysis and genotyping was performed by pcr-rflp method. results: according to obtained genotyping and also statistical analysis, it was observed that between the patients and control group a significant difference existed and the genotypes of tc and cc were high in control group compared to the patients group. conclusion: the host genetic factors can plays an important role in pathogenesis of hbv infection, genetic variations in infgr1 was related to several diseases, in this study we surveyed association between -56t/c (snp) in infgr1 and chronic hbv infection, the results of our study showed that presence of c and tc alleles in our population is related to decrease risk susceptibility to chronic infection.