Association of nesfatin-1 levels with fasting and postload glucose levels in patients with hypothyroidism

Nesfatin-1, which is known as an anorexigenic peptide, has a potential role in the control of glucose/insulin regulation. we aimed to investigate serum nesfatin-1 levels in patients with untreated hypothyroidism due to hashimoto’s thyroiditis and correlate with fasting plasma glucose (fpg) and postload glucose levels. this study included 40 patients with hypothyroidism (mean age; 32.3±12.6 years, body mass index (bmi); 27.8±7.9 kg/m2) and 54 age and bmi matched healthy control group (mean age; 29.3±8.5 years bmi; 29.7±7kg/m2). all subjects underwent a 75 gr oral glucose tolerance test. serum nesfatin 1 levels were similar among the hypothyroid subjects and control group (14.1±13.4 vs 16.7±15.4 ng/ml, respectively) (p=0.152). fpg (95±8 vs 96.6±7.9 mg/dl) and 2 h postload glucose (113.6±26.7 vs 113.1±27.5 mg/dl) levels did not differ between the two groups (p=0.339, p=0.976 (respectively)). there was no significant correlation between nesfatin-1 and free t3, free t4, tsh, anti-thyroglobulin autoantibody (tgab) and antithyroid peroxidase autoantibody (tpoab) (p>0.05). while nesfatin 1 levels did not correlate with fpg, 2 h postload glucose, the homeostasis model assessment (homair), total-cholesterol, hdl-cholesterol and ldl-cholesterol levels, it showed a negative correlation with triglyceride levels (p=0.008). nesfatin-1 levels were not associated with fpg and postload glucose levels in patients with hypothyroidism.