Lamotrigine induced seizures in juvenile myoclonic epilepsy

Juvenile myoclonic epilepsy (jme) is a common epileptic syndrome. before the development of the new antiepileptic drugs (aeds) after the 1990s, valproate (vpa) was the first-line treatment in juvenile myoclonic epilepsy. however, the frequent adverse effects and the risk for teratogenicity have resulted in a search for alternative therapies especially in women. lamotrigine (ltg), topiramate, and levetiracetam, have been used as monotherapy or adjunctive therapy for juvenile myoclonic epilepsy in small patient series. we report a case of a thirty one-years-old female suffered from severe aggravation in myoclonic and generalized tonic-clonic (gtc) seizures after decreasing the lose of vpa and initiating ltg.