deficits in striatal dopamine and hippocampal serotonin following induction of anxiety/depressive-like behaviors by bisphenol a

Background: anxiety and depression are common nonmotor symptoms of parkinson's disease (pd). objectives: we investigated whether bisphenol a (bpa) is capable of inducing anxiety/depressive-like behaviors and neurotransmitter alterations that are similar to those observed in pd. materials and methods: to test this hypothesis, we used a zebrafish animal model and conducted behavioral and histological assays. results: bpa produced anxiety/depressionlike behavioral signs for 14 days following administration. altered behavioral responses were accompanied by reductions of striatal dopamine transporter, and decrease in hippocampal 5ht content. conclusions: these results suggest that the nigrostriatal pathway might play a role in the etiology of anxiety/depression. furthermore, dopamine transporter function, in particular, might play a critical role in the pathophysiology of anxiety/depression.