the association between low levels of serum vitamin d and the duration and severity of parkinson's disease

Background: parkinson’s disease is a neurodegenerative disorder more commonly seen in people aged over 50 years old. the etiology of the disease is unknown, yet the impact of factors, such as vitamin d as a hormone on parkinson’s disease has been demonstrated in previous studies. objectives: the aim of the current study was to investigate the role of low levels of this factor on the severity and duration of the disease. methods: in 2015 to 2016, the current researchers conducted this case-control study on 50 patients with parkinson’s disease and 50 healthy subjects as the control group in babol, iran. demographic information (age, gender, and education), serum levels of vitamin d in the two groups, disease duration, disease severity, and cardinal features of the disease in the patient group were investigated. data were analyzed using the spss 23 software with the t-test, kruskalwallis, mann-whitney, and adjusted logistic regression. results: themeanserum vitamindlevels was 27.2827.75 (ng/ml) and 32.0017.76 (ng/ml) in patient and control groups, respectively (p = 0.009). in terms of the duration of the disease, 34 (68%) patients had the disease for less than five years, nine (18%) for five to ten years and seven (14%) for more than ten years. the duration was significantly higher in females (p = 0.001). logistic regression analysis with adjusted demographic variables showed that the observed lower levels of serum vitamin d in cases compared with the control group was statistically significant (or = 4.17; 95% ci: 1.37, 12.71; p = 0.012). conclusions: there was a significant relationship between low serum vitamin d levels and the duration and severity of parkinson’s disease in patients under 60 years of age.