the effect of training at different temperatures on the gene expression of glut4 and insulin receptor in the brown adipose tissue of streptozotocin-induced diabetic rats

Background and objective: diabetes is one of the health problems in all societies. the aim of the present study was to investigate the effect of a period of training at different temperatures on the gene expression of glut4 and insulin receptor in the brown adipose tissue of diabetic rats. material and methods: in this experimental study, 21 diabetic rats were randomly divided into 3 groups of 7 animals, including: (1) control (c), (2) swimming training at 5° c (s5ºc), and (3) swimming training at 36° c (s36ºc). water swimming training was performed at 5±2° c and 36±2° c for six weeks, 5 sessions per week and 2-4 minutes per session. data were analyzed using one-way analysis of variance and tukey’s post hoc test at the significance level of p≤0.05. results: the gene expression of glut4 and insulin receptor in the s5º c and s36º c groups was significantly (p = 0.0001) higher than the control group. also, the gene expression of glut4 in the s36º c group was higher than the s5º c group (p = 0.001), and the expression of insulin receptor in the s5º c group was significantly (p = 0.001) higher than the s36º c group. conclusion: swimming training at 5º c and 36º c significantly increased the gene expression of glut4 and insulin receptor in the brown adipose tissue of diabetic rats.