the anti-inflammatory effects of aerobic training and octopamine consumption in the heart tissue of rats fed deep-fried oil

Background and objectives: it has been reported that deepfried oils (dfos) used in the preparation of fast foods can affect the immune system. on the other hand, regular physical activity and proper nutrition, in addition to affecting physical function, have a tremendous impact on the immune system. the aim of the present study was to investigate the antiinflammatory effects of aerobic training (t) and octopamine (o) consumption in the heart tissue of rats fed dfo.methods: in this experimental study, 25 male wistar rats with mean age of 20 weeks old and weighing 300 350 were purchased and divided into 5 groups of 5 rats, including: 1) control, 2) dfo, 3) dfo+t, 4) dfo+o and 5) dfo+t+o. during four weeks, groups 2 5 received dfo by gavage; groups 3 5 ran on treadmill (with speed of 50% vo2max in the first week which reached 65% vo2max in the last week) five sessions per week and 20 minutes per session and groups 45 received 81 mu;mol/kg octopamine supplement peritoneally for 5 days per week. nuclear factor kappa b (nf kappa;b) and tumor necrosis factoralpha (tnf alpha;) gene expression were measured in heart tissue.results: dfo significantly increased nf kappa;b (p=0.005) and tnf alpha; (p=0.001) gene expression levels; t significantly on decreased nf kappa;b (p=0.01) and tnf alpha; (p=0.007) gene expression levels; o consumption significantly decreased nf kappa;b (p=0.001) and tnf alpha; (p=0.001) gene expression levels; however, the interactive effects of t and o consumption on nf kappa;b (p=0.57) and tnf alpha; (p=0.20) gene expression levels was not significant.conclusion: it seems that t and o consumption alone have antiinflammatory effects on the heart tissue of rats fed dfo, however t and o do not have antiinflammatory interactive effects.