lack of association between ptpn22 (+1858 c>t) rs2476601 polymorphism and susceptibility to rheumatoid arthritis (ra) in northeast of iran

Background and objectives: rheumatoid arthritis (ra) is an autoimmune disease with a complex genetic background. the protein tyrosine phosphatase non-receptor type 22 (ptpn22) is a lymphoid specific protein tyrosine phosphatase which is involved in negative regulation of t cell response. several studies have assessed the association between ptpn22 single nucleotide polymorphisms (snps) with ra susceptibility. here, we aimed to assess the association of ptpn22 (1858 c>t) variant with the susceptibility to ra in northeast of iran. methods: a total of 127 ra patients and 119 age- and sex- matched healthy donors were enrolled. the polymerase chain reaction (pcr) followed by restriction fragment length polymorphism (rflp) technique (pcr-rflp) was applied to detect ptpn22 (1858 c>t) snp. spss 22.0 software was used to analyze data using relevant statistical tests. results: comparison of allele and genotype frequencies of ptpn22 (1858 c>t) snp in ra patients and healthy donors revealed no significant association with ra susceptibility. conclusion: the present study suggests that the ptpn22 (1858 c>t) genetic variants are not associated with ra susceptibility and disease activity. while this is the first report from northeast of iran, further studies are needed to confirm these findings.