evaluation the response to treatment of vitamin d deficiency in iranian overweight/obese children

Background: recently the prevalence of obesity and its comorbidities has increased in children, in the worldwide. some evidences show that there is a reverse relation between the serum level of 25-hydroxyvitamin d[25(oh)d] and body mass index (bmi). the purpose of this study was scrutiny response to treatment vitamin d deficiency in obese/overweight children.materials and methods: in a randomized clinical trial, cross sectional study 60 children aged 5 -15 year- old with bmi≥85% were entered. after obtaining of informed consent the calcium, phosphorous, alkaline phosphatase, 25(oh) d and parathyroid hormone (pth) levels were measured after 8 hours of fasting. according to intensity of vitamin d deficiency, intra muscularly vitamin d3, 300,000 to 600,000 unit was prescribed. all parameters were rechecked after 1 month. data were analyzed with spss- 20 software.results: among total 60 subjects, 49 children (81.7%) were overweight and 11 children (18.3%) were obese. also, all of subjects had vitamin d deficiency. after intervention only 35% got normal level of vitamin d. mean level of vitamin d in girls were lower than boys. average level of vitamin d rose significantly after intervention in both overweight and obese groups (p<0.05). the mean pth level was reduced significantly after intervention in overweight children (p<0.05). mean levels of calcium and phosphoruswere increased in two groups after intervention, but this is not significant (p>0.05).discussion: with considering high prevalence of vitamin d deficiency in overweight/obese children, low response to treatment and multiple after math complications, we suggest more attention to vitamin d deficiency and renewal and early intervention in these children.