case report: werner syndrome with non-alcoholic fatty liver disease and elevated liver function tests in a 17-year-old male

Background: werner syndrome (ws) is a rare autosomal recessive disorder characterized by premature aging and various metabolic complications. non-alcoholic fatty liver disease (nafld) is primarily associated with metabolic syndrome, but its occurrence in young patients with ws is rarely reported. we describe the case of a 17-year-old male diagnosed with werner syndrome who presented with grade 2 nafld and elevated liver function tests (lfts).case presentation: a 17-year-old male, born to consanguineous parents, presented with clinical features suggestive of premature aging. genetic testing confirmed a mutation in the wrn gene, establishing a diagnosis of werner syndrome. liver ultrasound revealed grade 2 fatty liver, and liver biopsy confirmed moderate steatohepatitis (activity grade 6, stage 2). elevated liver enzymes were observed, although other metabolic parameters were within normal limits.conclusion: this case highlights the importance of recognizing liver involvement in patients with werner syndrome and underscores the need for routine monitoring and a multidisciplinary approach to management. genetic counseling is essential for families with consanguineous backgrounds to reduce the risk of autosomal recessive conditions like ws.