synbiotic supplementation in type one diabetes mellitus: a randomized controlled clinical trial

Background: limited studies have been conducted on the effect of synbiotics supplementation on type 1 diabetes mellitus (t1dm). the current study aimed to evaluate the impacts of synbiotic supplementation on glycemic parameters, lipid profile, and vitamin d levels in children with t1dm.methods: in this double-blind, randomized controlled trial, 86 t1dm patients aged 4-18 were randomly divided into two equal groups. one group received insulin and a synbiotic supplement once daily for 12 weeks; another group received insulin and a placebo. fbs (fasting blood sugar), hba1c (hemoglobin a1c), triglycerides, cholesterol, hdl (high-density lipoprotein), ldl (low-density lipoprotein), and vitamin d levels were measured at the beginning and end of the study in both groups.results: the trend of fbs, hba1c, triglycerides, cholesterol, hdl, ldl, and vitamin d changes was not significant over time in both groups. based on the analysis of covariance, the means of fbs and hba1c were lower in the intervention group (p=0.048 and 0.025, respectively). however, no significant changes in triglycerides, cholesterol, hdl, ldl, and vitamin d levels were observed between the two groups (p= 0.291, 0.291, 0.952, 0.140, and 0.557, respectively).conclusion: it’s suggested that insulin treatment in combination with synbiotic supplementation could improve fbs and hba1c in t1dm children but had no effects on lipid profile and vitamin d levels.