Investigating Vitamin D Serum Levels in Children with Congenital Heart Disease Compared with the Healthy Control Group

Backgroundvitamin d is a fat-soluble vitamin that has an important function in bone metabolism, muscle activity, nervous system, and immunity. in this study, we compared the vitamin d level of children with congenital heart disease (chd) with healthy control.materials and methodsthis case-control study was conducted on 56 children with chd diagnosed with echocardiography and 56 healthy children with no sign of chd matched for age, sex, and use of vitamin d supplementation. participants were gathered from those who referred to the cardiac clinic of vali-easr hospital, birjand, iran, in 2017. two ml of the blood sample was taken from all participants and serum vitamin d was assessed using roche diagnostic kit (germany). the data analysis was achieved using spss software version 16 with descriptive statistics and chi-square test. resultsthe median age of participants was 7 months (ranged1-24). the mean vitamin d serum level of all participants was 32.19 ng/ml (sd=28.79) (normal > 20). the level of vitamin d in the case and control group was 16.82 ng/ml (29.85-9.38), and 34.95 ng/ml (46.60-26.52), respectively; and this difference was significant (p<0.05). in the chd patients group, 15 patients had vitamin d deficiency and 5 patients had high vitamin d levels. in the healthy patients’ group, these numbers were 2 and 21, respectively.conclusionbased on the results, children with chd had significantly lower levels of vitamin d; therefore, we suggest more vitamin d supplement be used for patients with chd than healthy children.