Evaluation of Antibiotic Resistance Trend among Cystic Fibrosis Patients: A Single Center Study from 2014-2019

Background: antibiotic resistance in cystic fibrosis (cf) patients has been a serious issue in their survival. the objective of this study was to investigate the antibiogram trend in serial admissions among cf patients. materials and methods: in this retrospective descriptive-analytical study, from 2014 to 2019, 95 known cases of cf patients with repeated admissions at masih daneshvari hospital, tehran, iran, were evaluated. demographic data and para-clinical parameters were evaluated. fourteen antibiotic disks were used to determine antibiotic resistance. resistance trend in 2014 and 2018 was compared. results: out of 95 patients, 48 patients (52.2%) were female. the mean age of patients was 19.43 ± 6.7 years. pseudomonas positive culture in the first admission was 68.4%; while it was 45.3% in the second admission and 28.4% in the third admission (p> 0.05). staph positive culture was 20%; 18.9%, and 16.8%, respectively (p> 0.05). pseudomonas aeruginosa was the most sensitive to vancomycin (93.8%), followed by colistin (93.3%) and ceftazidime (65.2%). there was no correlation between patients' age and multidrug resistance (mdr). fev1 was significantly lower in both the patient with positive pseudomonas (p-value: 0.01), and culture and mdr (p= 0.023). furthermore, in terms of antibiotic resistance over time, resistance to colistin statistically decreased from 25% in 2014 to 2% in 2018 (p= 0.02). conclusion: vancomycin, colistin, ceftazidim, imipenem, amikacin, and gentamycin had the highest drug sensitivity; while cefotaxime, clindamycin, and chloramphenicol antibiotics had a low sensitivity. from 2014 to 2019, resistance to colistin dramatically decreased.