Acute Bronchiolitis Treatment: A Comparison of Montelukast, Aminophylline and Ventolin in Pediatric Patients: A Clinical Trial Study

Background: the effects of various drugs on reducing the severity of bronchiolitis symptoms in children have been identified. we sought to make a comparison of montelukast, aminophylline and ventolin (intravenous salbutamol) in the treatment of acute bronchiolitis in patients ranged between 1 and 24 months old. materials and methods: this study used a randomized clinical trial method. statistical population of the study included all patients younger than 2 years and older than one month who were admitted to ali-ibn-abitaleb hospital in zahedan-iran. two hundred patients were divided into four groups using a random number table method. the first group received supplemental monotherapy with montelukast 4 mg/kg daily for 7 days. the second group received 1 mg/kg aminophylline injection every 12 hours. the third group or the control group received supportive measures. the fourth group received 0.15 mg/kg ventolin nebules with dose of 2.5 mg. symptoms were measured on days 2, 5 and 7, and the number of hospital admissions days was also assessed in four groups and compared. results: the results showed that the consumption of montelukast and ventolin nebules had no significant effect on bronchiolitis treatment in comparison with the control group (p>0.05). using aminophylline did not reduce the symptoms of bronchiolitis in comparison with the control group (p<0.05). the results also showed that using aminophylline in group b did not produce better results in decreasing the severity of the symptoms of bronchiolitis in comparison with montelukast group and ventolin group (p<0.05). conclusion the results showed that consumption of aminophylline, montelukast and ventolin had no significant effect on bronchiolitis in comparison with the control group.