Association of Helicobacter Pylori Infection with Cardiometabolic Risk Factors among Iranian Adolescents: the CASPIAN III Study

Background: at least half the world’s population is colonized the stomach by helicobacter pylori (h. pylori) which are a key constituent of the human microbiome. the aim of this study was to investigate the association of cardiometabolic risk factors with h. pylori infection in iranian adolescents. materials and methods: the current study was conducted along with the third survey of a national school-based surveillance system in iran, entitled childhood and adolescence surveillance and prevention of adult non-communicable disease (caspian) study. detailed questionnaires on demographic, socioeconomic, dietary, and health-related information of the participants were filled by one of the parents under supervision of trained health-care workers. trained healthcare professionals measured anthropometric indices, blood pressures according to standard protocols. fasting venous blood was examined for fasting blood sugar and lipid profile. results: overall 882 serum samples were suitable for testing. h. pylori antibody was found in 643 serum samples (72.9%). among cardiometabolic risk factors, only the mean weight of participants was different between two groups (44.6±11.8 in h. pylori positive and 42.8±11.3 in h. pylori negative group; p=0.04). overall, 5.1% of adolescents with positive h. pylori tests were overweight or obese, while 1.7% of negative ones were so (p=0.02). in the multivariate regression model, h. pylori seropositivity increased the risk of overweight (or, 3.3; 95%ci, 1.2-9.3; p= 0.03). in the multivariate model, association of other cardiometabolic risk factors with h. pylori infection was not statistically significant (p>0.05). conclusion: results of present study showed that h. pylori infection was associated with excess weight in adolescents. h. pylori eradication may be decrease the risk of obesity.