seroprevalence of hepatitis b and c virus infection in children with chronic kidney diseases; a historical cohort study

Background the prevalence of hepatitis b and c in iranian children with chronic kidney disease is limited. therefore, the present study intends to assess the prevalence of hepatitis b and c in children with chronic kidney disease (ckd). materials and methods: the present study is a historical cohort study which was conducted in a window period of 25 years in children’s medical center in tehran, 1991-2016. data (age, gender, duration of hemodialysis, kidney transplant, and severity of ckd) were extracted from hospital profiles of admitted patients. infection with hepatitis b or c viruses was considered as primary outcome. at the end, results were reported as odds ratio (or) with a confidence interval of 95 per cent (95% ci). results: three hundred and fifty five children (50.1% boys, mean age of 54.5±89.0 months) were assessed. hepatitis b and hepatitis c were detected in 9 (2.5%) and 5 (1.4%) children, respectively. ten children had either hepatitis b or c infection with a prevalence of 2.8% (95% confidence interval: 1.4% to 5.1%). multivariable analyses showed that association between the need for hemodialysis (or=13.52; p=0.083) and severity of chronic kidney disease (or=0.28; p=0.072) with incidence of hepatitis infection was borderline. however, risk of hepatitis b or c infection was 5.9-fold greater in girls compared to boys (or=5.94; p=0.047). conclusion: the present study showed that the prevalence of hepatitis b and c were 2.5% and 1.4%, in children with chronic kidney disease, respectively. the prevalence of mentioned infections was significantly higher in girls compared to boys.