Cow’s Milk Sensitization in Young Children with Gastroesophageal Reflux Disease

Background recent reports have suggested that gastroesophageal reflux disease (gerd) is link with cow’s milk (cm) sensitization in children. the aim of this study was to determine the frequency of cm sensitization in young children with gerd.materials and methods this cross- sectional study included 33 children (median age, 2.93±1.90 years) with gerd according to a valid gastroesophageal reflux questionnaire, and 33 healthy children (median age, 3.39±1.90 years). cma was diagnosed by skin test, serum specific immunoglobulin e level and atopy patch test to milk in both patient and control groups.results twenty-four children with gerd were positive for at least one of the diagnostic tests for cm sensitization compared to 13 children in control group (odds ratio [or] = 1.78; 95% confidence interval [ci]: 1.14 to 2.80). unlike the results of skin prick tests and specific immunoglobulin e (ige) levels to milk which showed no difference between children with gerd and healthy controls, there was a significant difference in the results of patch test (or=2.06; ci95%: 1.46 to 2.91). conclusion based on our results, cm sensitization is 1.7 higher in children with gerd than non- gerd children. patch testing preferably would better to perform for diagnosis of cm sensitization in those children with gerd.