Effect of Treatment with Vitamin D on Maternal and Neonatal Indices in Pregnant Women with Hypocalcemia: A Randomized Controlled Trial

Background the impact of concomitant vitamin d deficiency and maternal hypocalcemia on fetal growth has is not clear. the aim of this study was to determine the effect of treatment with vitamin d on maternal and neonatal indices in pregnant women with hypocalcemia. materials and methods this clinical trial was conducted on 110 pregnant women (22-26 weeks of gestational age) with simultaneous mild hypocalcemia (8 < serum calcium< 8.5 mg/dl) and vitamin d deficiency (25 (oh) d< 75 nmol/l). the study subjects were randomly allocated to intervention (n=55) and control (n=55) groups. in the control group, the subjects were given daily prenatal capsule until delivery. in the intervention group, the subjects were given 50,000 units vitamin d weekly for eight weeks in addition to prenatal capsules until delivery similar to the control group. at delivery, maternal calcium and 25 (oh) d level and neonatal indices (weight, height, and head circumference) were measured and compared between the groups. results at delivery, mean maternal vitamin d level was 97.5±23.4 nmol/l in the intervention group and 48.9±17.2 nmol/l in the control group, respectively (p<0.001). mean maternal calcium level in the intervention group was higher than the control group (9.0±0.6 mg/dl vs. 8.8±0.5 mg/dl) but the difference was not statistically significant (p>0.05). mean neonatal weight, height, and head circumference were not significantly different between the two groups (p>0.05). conclusion in pregnant women with mild hypocalcemia, treatment with vitamin d would not have effect on mean serum calcium and neonatal indices.