UJIAKTIVITAS PENGHAMBATAN ENZIM ALFA-GLUKOSIDASE PADA BEBERAPA TANAMAN SUKU EUPHORBIACEAE

Diabetes mellitus (types 1 and 2) is recognized as a serious global health problem that characterized by hyperglycemia. type 2 diabetes is more common in diabetic populations. in type 2 diabetes mellitus, inhibition of α-glucosidase is a useful treatment to delay the absorption of glucose after meals. avoiding the adverse effects of current agents, it is still necessary to search alternative for better options. plants have been a rich source of α-glucosidase inhibitors. in this research, screenings based on chemotaxonomic approach to determine the class of chemical constituents and to know α-glucosidase inhibiting activity of some plants from euphorbiaceae. the simplisia powder was extracted using ethanol 80% by reflux. measurement of inhibitory activity of α-glucosidase performed using a spectrophotometer uv-vis. in vitro assays of α-glucosidase activity showed 14 extracts had ic50 values of between 2.34 μg/ml and 64.78 μg/ml, which were lower than that of acarbose (117.20 μg/ml). leaves extract from antidesma celebicum had the highest α-glucosidase inhibiting activity with an ic50 of 2.34 μg/ml. the results of phytochemical screening in 15 extracts generally contain glycosides, terpenoids/ sterols, tannins, saponins and alkaloids.