PENGEMBANGAN METODE INDUKSI TUKAK LAMBUNG

Scientific evaluation on pharmacological activity of medicinal herbs required reproducible and valid method-induced ulcer models in animal. in this study, the method of antiulcerogenic effect was investigated using several inducers. the male white sprague-dawley rats divided into five groups which were orally administrated water, indomethacin (48 mg/kg bw), aspirin-hcl (150 mg/kg bw), 96% ethanol (1 ml/200 g bw), and 80% ethanol (1 ml/200 g bw), respectively. the result of this study showed that the group was induced with 80% ethanol demonstrated the highest ulcer index. histological examination of the stomach showed abnormality of mucosa cells on the aspirin-hcl, 96% ethanol, and 80% ethanol-induced gastric ulcer model in rats.