Recurrent pregnancy loss in a subject with heterozygote factor V Leiden mutation

Recurrent pregnancy loss is usually defined as the loss of two or more consecutive pregnanciesbefore 20 weeks of gestation, which occurs in approximately 5% of reproductive-aged women. ithas been suggested that women with thrombophilia have an increased risk of pregnancy loss andother adverse pregnancy outcomes. thrombophilia is an important predisposition to blood clotformation and is considered as a significant risk factor for recurrent pregnancy loss. the inheritedpredisposition to thrombophilia is most often associated with factor v leiden mutation,prothrombin g20210a mutation, and methylenetetrahydrofolate reductase c677t and a1298cgene variants. the net effect is an increased cleavage of prothrombin to thrombin and excessiveblood coagulation.