interleukin-10 gene polymorphisms modulate the risk of infertility in chlamydia trachomatis positive kurdish women in erbil province

Background: there is evident inter-individual variability in women’s responses to chlamydial infections and reproductive tract problems. women’s genetic variations within the interleukin-10 (il-10) gene have been linked to variances in response to chlamydia trachomatis infection. this study was aimed to demonstrate the profound association of il-10 with infertility and demonstrate the role of il-10 (-592 c/a rs1800872) and (-1082 a>g rs1800896) single nucleotide polymorphism (snps) gene in the susceptibility and severity of a c. trachomatis infection.method: in this evaluation study, serum il-10 concentration was measured in 134 women diagnosed with infertility and 50 healthy volunteers by enzyme-linked immunosorbent assay (elisa). the tetra-amplification refractory mutation system-pcr (t-arms-pcr) analysis was performed to detect the genotyping of the rs1800872 and rs1800896 snps genes.result: both female groups were positive for anti-chlamydial igm antibody, but the intensity of response differed between cases. at the same time, the incidence of genital c. trachomatis by pcr was 46.2% in infertile women. the serum concentration of il10 was lower in infertile women than healthy participants and higher in infertile c. trachomatis-positive women compared to infertile c. trachomatis-negative in all groups except endometriosis (endo) infertility. in rs1800872, the ca genotype and c allele are associated with an increased risk for infertility, except in polycystic ovarian syndrome (pcos), which is an a allele. in the case of rs1800896, the ag genotype and g allele show a greater risk for infertility.conclusions: our results confirmed that rs1800872 and rs1800896 gene polymorphisms were associated with an increased risk of c. trachomatis infection.