pro-oxidant/ antioxidant balance correlates with red blood cell indices and anemia severity in the anemic patients

Background: the oxidant/ antioxidant balance is disrupted in anemia. antioxidant capacity depends on antioxidant enzyme activity and some trace elements. this study aimed to evaluate oxidant/ antioxidant status and its correlation with red blood cell indices and anemia severity in anemic patients.methods: blood samples were taken from 90 anemic patients and 95 healthy people. circulatory mir-122 was assayed by real-time pcr. malondialdehyde (mda), pro-oxidant/ antioxidant balance (pab), supper oxide demitasse (sod), glutathione peroxidase (gpxs) activity, total antioxidant capacity (tac), and zinc were measured by colorimetric method. selenium was also determined using atomic absorption. results: selenium and zinc decreased significantly in the case group (**p=0.004 and ***p=0.000). the amount of mir-122 up-regulated in the anemia (**p=0.003). mda was significantly raised in the case vs control (***p=0.0002). pab was higher in the case group (**p=0.005). sod and gpxs activity was decreased along with tac in anemic patients (*p=0.02, **p=0.008, *p=0.038). zinc and pab levels correlated with some red blood cell indices. pab was associated with anemia severity.conclusion: increased pab and decreased zinc/selenium increased oxidant levels in anemic patients. rbc indices and anemia severity were correlated with oxidant/ antioxidant somewhere.