sirt1 gene polymorphisms are associated with urinary bladder cancer in an iranian population

Background: the present study was undertaken to evaluate the possible association between silent information regulator of transcription 1 gene (sirt 1) polymorphisms and risk of urinary bladder cancer (ubc) in an iranian population. methods: the sirt1 polymorphisms rs3758391 t/c and rs369274325 g/a were evaluated in 120 iranian bladder cancer patients and 118 healthy individuals as the control group. the sirt1 rs369274325 g/a and rs3758391 t/c polymorphisms were genotyped using tetra-primer arms pcr and pcr-rflp methods, respectively. results: the sirt1 rs3758391 tt genotype occurred significantly more frequently in the ubc patients than in the controls (13.3 vs. 1.7%) in both the additive and recessive models due to a significant difference in either of additive (tt vs. cc; or= 9.529, p = 0.003) or recessive models (tt vs. cc + ct genotype; or= 8.923, p = 0.002). also, for rs369274325, the ag genotype was found in a significantly greater percentage of ubc patients than in controls (75.8 vs. 43.2%, respectively, p < 0.0001. conclusions: our preliminary study suggests that sirt1 rs3758391 t/c and rs369274325 g/a polymorphisms may confer an increased risk of bladder cancer in our patients.