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purification of pia and rsesc as putative vaccine candidates against staphylococcus aureus
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نویسنده
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bahonar sara ,ghazvinian maryam ,haghshenas mohamad reza ,goli hamid reza ,mirzaei bahman
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منبع
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reports of biochemistry and molecular biology - 2019 - دوره : 8 - شماره : 2 - صفحه:161 -167
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چکیده
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Background: staphylococcus aureus is predominant at sites of biomaterial-associated infection (bai) and frequently infects hospitalized individuals. methods: the polysaccharide intercellular adhesin (pia) and s. epidermidis rsesc protein, major macromolecules in biofilm formation, were purified under native conditions and cloned and expressed in a prokaryotic host. results: purification of the macromolecules was confirmed by ftir and western blotting. conclusions: the s. epidermidis sesc protein and pia were successfully purified. both are considered as vaccine candidates.
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کلیدواژه
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biofilm formation ,polysaccharide intracellular adhesin ,staphylococcus aureus
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آدرس
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mazandaran university of medical sciences, faculty of medicine, molecular and cell biology research center, department of medical microbiology and virology, iran, mazandaran university of medical science, faculty of medicine, department of medical microbiology and virology, iran, mazandaran university of medical science, faculty of medicine, department of medical microbiology and virology, iran, mazandaran university of medical science, faculty of medicine, department of medical microbiology and virology, iran, mazandaran university of medical sciences, faculty of medicine, molecular and cell biology research center, department of medical microbiology and virology, iran
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پست الکترونیکی
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b.mirzaei@mazums.ac.ir
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Authors
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