vitamin d and mirna-155 in behçet’s disease: possible association with the disease and disease activity

Background: vitamin d (vit d) controls inflammation and immunity. in behçet’s disease (bd), microrna-155 is recognized as a significant immune response regulator. we aimed to investigate the role of vit d on immunomodulation and downregulation of inflammatory pathways associated with bd and detect the role of mirna-155 in bd.methods: mirna-155 expression by real time -polymerase chain reaction (rt-pcr), and vit d, nuclear factor kappa-light-chain-enhancer of activated b cells (nf-κb), and tumor necrosis fact of tnf-α) expression by enzyme linked immunosorbent assay (elisa) were assessed.results: bd patients had a significantly higher relative expression of microrna-155 (p< 0.001), it was significantly related to vascular manifestations (p< 0.001). vit d relative expression was significantly low in bd (p< 0.001). there was a significant rise in mirna-155 in the active group compared to the inactive group (p< 0.001). a significant decrease in vit d levels (iu) was found in inactive and active individuals suffering from bd when compared to controls (p< 0.001). a significant rise was found in vit d levels in inactive bd cases (p< 0.001). a significant positive correlations were found between mirna-155, nf-κb, tnf-α, and negative correlations with vit d relative expression in bd patients.conclusions: mirna-155 relative expression is higher in bd is significantly related to vascular manifestations. it may have a relationship to disease activity. vitamin d relative expression is significantly low in bd patients, which can significantly influence immunomodulatory bd therapy. vitamin d deficiency linked to active bd.