the ratio of cysteine-rich angiogenic inducer 61 to microrna -155 expression as a preeclampsia diagnostic marker and predictor of its severity

Background: preeclampsia (pe) is a multisystem pregnancy disorder that increases maternal-perinatal morbidity and mortality significantly. microrna-155 (mir-155) overexpression in the sera of pregnant women has been linked to preeclampsia. researchers discovered that mir-155 acts during pregnancy by down-regulating and reducing the cysteine-rich angiogenic inducer 61 (cyr61), which causes local ischemia as well as oxidative stress.methods: the level of mir-155 expression in all serum samples was quantified using real-time polymerase chain reaction (rt-pcr), and serum cyr61 was measured using enzyme-linked immunosorbent assays. together with the cyr-61/mir-155 ratio, they were evaluated as biomarkers for pe pathogenesis and severity prediction.results: mir-155 expression, serum cyr61 levels, and cyr-61/mir-155 ratios were all significantly higher in pe patients compared to the control group. serum cyr61 levels and the cyr-61/mir-155 ratio differed significantly between mild and severe pe patients.conclusion: mir-155 expression, serum cyr61 levels, and cyr-61/mir-155 may serve as biomarkers for pe pathogenesis and severity prediction.