association of rs7217186 polymorphism of arachidonic acid 15-lipoxygenase (alox15) gene with susceptibility to allergic rhinitis

Background:  allergicrhinitis (ar) is an inflammatory disorder of the nasal mucosa, caused by exposure to environmental allergens. it is known that 15-lipoxygenase (15-lox) is involved in the biosynthetic pathways of anti-inflammatory lipid mediators, including resolvins and protectins. methods: in this study, which was performed on 130 ar patients and 130 healthy controls, we aimed to investigate the association of susceptibility to ar with two selected single-nucleotide polymorphisms (snps), that is, rs2619112:a>g and rs7217186:c>t, in the intron regions of arachidonic acid 15-lox (alox15) gene, using snpinfo and regulome db tools.results: the results showed that the ct genotype of rs7217186: c>t was significantly associated with the increased risk of ar compared to the cc genotype (p= 0.037, or=1.943, ci: 1.038-0.638). however, there was no strong evidence of the association of rs2619112: a>g with susceptibility to ar (p> 0.05).conclusions: the present results indicated that rs7217186 polymorphism of alox15 gene might be a potential biomarker for susceptibility to ar.