association of circulating circular rnas (hg38_circ_0008980, and circdlgap4) in diagnosis, diseases severity, and prognosis of ischemic stroke

Background: fast diagnosing ischemic stroke (is) is a critical issue in clinical studies, as it allows more effective therapy and stops the progression of is. the blood level of circular rnas (circrnas) after stroke may be a rapid diagnostic marker.methods: in this study, the blood level of circrnas was evaluated using a real-time polymerase chain reaction (pcr). we used logistic and linear regression analysis to assess the potential of circrnas levels with the risk of is.results: circrna dlg associated protein 4 (circdlgap4) was decreased in patients compared with controls, and logistic regression showed its expression negatively associated with is risk. the expression level of human genome version 38_circular_0008980 (hg38_circ_0008980) was reduced significantly in patients with small vessel disease (svd), and the linear regression analysis showed a negative relationship between hg38_circ_0008980 expressions with svd subtype. hg38_circ_0008980 expression relative to controls showed a significant association with is risk.conclusions: taken together, we found a significant decrease in the level of hg38_circ_0008980 after is; it may act as a novel circrna in is pathophysiology with a positive correlation with stroke severity.