an association between gas5 rs145204276, neat1 rs512715, and meg3 rs4081134 gene polymorphisms and papillary thyroid carcinoma

Background: this study explores the association between growth arrest-specific 5 (gas5) rs145204276, nuclear paraspeckle assembly transcript 1 (neat1) rs512715, and maternally expressed 3 (meg3) rs4081134 polymorphisms and their impact on susceptibility to papillary thyroid carcinoma (ptc), considering differential expression of long noncoding rnas (lncrnas) in ptc.methods: a case-control study involving 125 papillary thyroid carcinoma (ptc) patients and 125 controls was conducted. genotyping of polymorphisms was performed using tetra-primer amplification refractory mutation system-polymerase chain reaction (arms-pcr) and pcr-restriction fragment length polymorphism (pcr-rflp) methods.results: no significant association was found between the two groups regarding genotypes and allelic frequencies of gas-5 145204276 and meg3 rs4081134 polymorphisms. genetic models also showed the same results. regarding neat1 rs512715, the ptc group had more gc genotypes and over-dominant models of neat1 rs512715 than controls, while controls showed a higher frequency of recessive models.conclusion: gas5 rs145204276 and meg3 rs4081134 polymorphisms showed no significant association with papillary thyroid carcinoma (ptc) risk. in contrast, neat1 rs512715 exhibited a significant impact on ptc development.