role of long non coding rnas, neat1 and lnc-dc expression in pediatric immune thrombocytopenic purpura

Background: pediatric immune thrombocytopenic purpura (itp) is an autoimmune disease; whose etiology is unknown. lncrnas are regulators of numerous actions, which participate in the development of autoimmune diseases. we evaluated the expression ofneat1 and lnc-rna in dendritic cell (lnc-dc) in pediatric itp.methods: sixty itp patients and 60 healthy subjects were enrolled in the present study; real-time pcr was performed to assess the expression levels of neat1 and lnc-dc in sera of children with itp as well as healthy children.results: both lncrnas, neat1 and lnc-dc were significantly upregulated in itp patients in comparison to controls (p <0.0001 and p= 0.001 respectively). furthermore, significant upregulation of the expression levels of neat1 and lnc-dc were observed in the non-chronic compared with chronic itp patients. also, there was significant negative correlation between each of neat1 and lnc-dc and platelet counts before treatment (r= -0.38; p= 0.003 and r= -0.461; p< 0.0001, respectively).conclusions: serum lncrnas, neat1 and lnc-dc could be used as potential biomarkers in differentiating childhood itp patients and healthy controls in addition to differentiating non-chronic from chronic itp which may provide a theoretical basis for the mechanism and treatment of immune thrombocytopenia.