the gpx-1 gene variants (rs1050450) in obesity: association with the risk of obesity and the gpx activity in females

Background: this study aimed to investigate the gpx-1 gene polymorphism (rs1050450), the level of oxidative stress and antioxidant parameters, and the lipid profile in an obese kurdish population in sulaimani, iraq.methods: in a case-control study,134 obese subjects and 131 normal bmi healthy individuals participated. the gpx-1 gene polymorphism was assessed by polymerase chain reaction-restriction fragment length polymorphism (pcr-rflp) method. the levels of biochemical and oxidative parameters were determined using photometric methods.results: the results showed that the fasting blood sugar (fbs), triglycerides (tg), and low-density lipoprotein cholesterol (ldl-c) levels were significantly higher in obese subjects compared to the control group. obese individuals had significantly lower levels of high-density lipoprotein cholesterol (hdl-c) than the controls. the gpx-1 activity and total antioxidant capacity (tac) levels were significantly elevated in the obese group compared to the control group (p=0.006, and p<0.001, respectively). no significant difference was detected in genotype and allele frequencies of gpx-1 (rs1050450) between obese and normal bmi groups. however, the presence of the gpx-1 tt genotype enhanced the risk of obesity in females by 1.93-fold (95% ci 1.04-3.58, p=0.036). in the total population, the gpx activity increased in the presence of tt compared to cc+ct and ct genotypes.conclusions: the study indicated that obesity is linked to significantly higher levels of fbs, tg, ldl-c, tac, and gpx activity and lower level of hdl-c. also, we found the gpx-1 gene polymorphism was associated with the risk of obesity in females and increased the gpx activity.