can micro rna-24 affect the cardiovascular morbidity in systemic lupus erythematosus by targeting ykl-40?

Background: systemic lupus erythematosus (sle) is an autoimmune disease with inflammatory nature. one of the leading causes of death in sle patients is cardiovascular (cvs) morbidity. mirna-24 is highly expressed in vascular endothelial cells (vecs). this dysregulated expression pattern is associated with dysfunction or even damage of vecs and leads to the occurrence of cardiovascular diseases. ykl- 40 is an inflammatory glycoprotein involved in the pathogenesis of endothelial dysfunction and thereby atherosclerosis. in this work, we aimed at illustrating the possible role of mir-24 and its target ykl-40 in the pathogenesis of the cvs morbidity associated with sle.methods: this work was conducted on 40 sle patients and 40 healthy controls. quantitative realtime pcr (qpcr) was done to estimate the expression level of mirna-24 in serum. in addition, we measured the serum level of ykl-40 using elisa.results: mir-24-fold change was found to be down-regulated, whereas serum ykl- 40 was upregulated among sle patients with observed significant and negative correlation between the two parameters.conclusions: our study provided an insight about the role of mir-24 and its target serum ykl-40 protein in the development of sle-related inflammation and atherosclerosis.