comparative study of new biomarkers in iraqi dm2 with and without complications

Background: recent research indicates that persistent inflammatory responses may contribute to the rise of diabetic nephropathy (dn) and diabetic cardiovascular disease (dcvd) in type 2 diabetes mellitus patients (dm2). numerous molecules associated with inflammation and angiogenesis have been implicated in the development and progression of dn and dcvd, respectively.methods: the subjects were separated into five groups: healthy controls (n= 25), type 2 diabetes mellitus patients (n= 30), type 2 diabetes mellitus patients with nephropathy dn (n= 30), and type 2 diabetes mellitus patients with cardiovascular disease dcvd (n= 30). the blood levels of irisin, il-8, hba1c, urea, and creatinine were determined.results: in current study there was high significant increased irisin levels (p< 0.001) in dn patients than other groups and a high significant decreased il-8 level in dcvd.conclusions: serum il-8 and irisin levels may serve as early indicators of dm2 problems (dn, dcvd).