impact of berberine on some epigenetic, transcription regulation and inflammatory biomarkers in a mice model of epilepsy

Background: epilepsy is one of the most widespread neurological disease worldwide. status epilepticus (se) is a life-threatening neurologic disorder. neuroprotective approaches are increasingly to discover a promising therapy to manage epileptic disorders. this study aimed to assess the impact of berberine on some epigenetic, transcription regulation & inflammatory biomarkers in a mice model of epilepsy. methods: this work was performed on; group i: (control), group ii: berberine‐treated control, group iii: epilepsy group, group iv: berberine‐treated epilepsy. groups were subjected to assessment of tumor growth factor-1ꞵ (tgf-1ꞵ), hypoxia inducible factor-1α (hif-1α), brain derived neurotrophic factor (bdnf) levels, histone deacetylase (hdac) activity & neuronal restrictive silencing factor (nrsf) gene expression. results: study showed significant increase in levels of hif-1α, tgf-1β, hdac activity & nrsf gene expression in epilepsy group & decrease in these levels in berberine treated epilepsy group. significant decrease in bdnf levels in epilepsy & elevation in them in berberine treated epilepsy group. conclusions: our study showed the anti-epileptic impact of berberine via its regulatory effect on some epigenetic, transcription factors & inflammatory biomarkers in a mice model of epilepsy.