analysis of micro-rna-144 expression profile in patients with multiple sclerosis in comparison with healthy individuals

Background: etiology of multiple sclerosis is non-clarified. it seems that environmental factors impact epigenetic in this disease. micro-rnas (mir) as epigenetic factors are one of the most important factors in non-genetically neurodegenerative diseases. it has been found mir-144 plays a main role in the regulation of many processes in the central nervous system. here, we aimed to investigation of mir-144 expression alteration in multiple sclerosis (ms) patients. methods: in this study 32 healthy and 32 ms patient's blood sample were analyzed by quantitative real-time pcr method and obtained data analyzed by rest 2009 software. results: analysis of real-time pcr data revealed that mir-144 increase significantly in ms patients compared to healthy controls. conclusions: the increase of mir-144 expression in ms patients is obvious. mir-144 can be used as a biomarker of ms and help to early diagnosis and treatment of this disease.