expression of vascular endothelial growth factor a and its type 1 receptor in supratentorial neoplasm

Background: vascular endothelial growth factor (vegf) is one of the primary angiogenesis regulators in solid cancers. brain solid tumors are life-threatening diseases in which angiogenesis is an important phase of tumor development and progression. in the present study, vegf-a and vegf receptor (vegf-r1) gene expression was evaluated in cns brain tumors. methods: vegf-a and vegf-r1 expression was quantified using real-time pcr on fresh biopsies of 38 supratentorial brain tumors compared to 30 non-tumoral tissues. then, the correlations were investigated with clinic-pathological and demographic factors of the patients. results: pcr product sequencing confirmed the validity of qrt-pcr. although vegf-a and vegf-r1 expression showed increasing trends with the progression of cell proliferation in different stages of astrocytoma, vegf-r1 did not meet the 95% confidence interval in other brain tumors. an increasing trend in vegf-a expression and a declining trend in vegf-r1 expression from stage i to ii were observed in meningioma. vegf-a and vegf-r1 expression had no significant correlation with age and gender. although peritumoral brain edema (ptbe) in astrocytoma was significantly associated with tumor stages, vegf-a and vegf-r1 were not correlated with ptbe in meningioma and metastasis. conclusions: vegf-a is a valuable factor for the prognosis of ptbe and malignancy in astrocytoma and is helpful in monitoring treatment approaches.