correlation between il-13rs20541(a> g) gene polymorphism and bronchial asthma among iraqi patients

Background: bronchial asthma has a complicated genetic history. changes in gene expression may be caused by gene polymorphism, cytokines play a central role. il-13 is an interleukin that has been shown to play a role in the disease's immunopathogenesis. the current study investigated the relationship between rs20541 of the il-13 gene and bronchial asthma in iraqi patients. methods: seventy-five patient and fifty healthy individuals as a control. the dna was extracted from blood samples. detection of genotype il-13snp (rs20541) were achieved by rflp-pcr. results: indicated a highly significant the levels of the ige, and il-13 in the patients compared to control at (p value≤ 0.01), (456.45±290.106 vs. 30.08±24.414), (59.5980±20.93750 vs.6.7034±4.10547) pg/ml respectively. result shows no significant differences in the frequency distributions of il-13 snp (rs20541) for all genotypes in cases and controls. a protective role of asthma, (or: 0.62; ci.95%: 0.23 - 1.6) and (or 0.89; ci.95%:0.42 - 1.89) were observed for wild type homozygous and heterozygous genotype respectively. whereas the aa genotype (42.7%) in cases and (34.0%) in control, that (or:1.44; ci.95%:( 0.66 - 3.07) mutant homozygous were risk factors of asthma among individuals. the genotypes of il-13 rs20541 (gg, ag, aa) among patients and controls were significantly correlated with ige and il-13 results at (p≤ 0.05). conclusions: aa genotype in case and control mutant homozygous were risk factors of asthma among individuals. it’s possible that this has a predisposing impact on the development of asthma.