serum caveolin-1 level is inversely associated with serum vaspin, visfatin, and hba1c in newly diagnosed men with type-2 diabetes

Background: the fluctuation in serum caveolin-1 (cav-1) concentrations is an important indicator of many diseases. irrespective of the actual cause, a significant reduction of serum cav-1 is associated with a significant increase in insulin secretion and hyperinsulinemia. the aim of the current study was to evaluate the relationship between serum cav-1, serum vaspin and visfatin in newly diagnosed men with t2dm. methods: eighty-two newly diagnosed men with t2dm were matched for age and body mass indexes (bmis) with a similar number of non-diabetic men. serum cav-1, vaspin and visfatin were assessed through enzyme-linked immunosorbent assay. fasting serum glucose (fsg), glycohaemoglobin a1c (hba1c) were both measured using automated method. in addition, waist-circumferences, waist-hip ratio, systolic (sbp), and diastolic blood pressure (dbp) were also obtained. results: serum concentration of cav-1(ng/ml) was significantly low in men newly diagnosed with t2dm, (2.334±0.7627) compared with non-diabetic controls (4.321±1.143), p< 0.0001. in contrast, patients with t2dm exhibited significantly higher serum concentrations of vaspin and visfatin (ng/ml), 142.4±60.53) and 2.99±1.091), than controls, 81.53±39.32) and 1.456±0.654), respectively, p< 0.0001. expectedly, patients with t2dm have significantly higher fsg, hba1c, systolic blood pressure (sbp), and diastolic blood pressure (dbp). conclusions: there was an inverse significant relationship between cav-1 and vaspin, visfatin, hba1c, fsg, and hypertension. this study suggests that serum cav-1 can be used as a diagnostic marker to predict t2dm in individuals and families under high risk.