uncoupling protein 2 expression modulates obesity in chronic kidney disease patients

Background: obesity is a multifactorial metabolic disease resulting from behavioral and genetic factors. obesity is linked to diabetes mellitus and hypertension, which are considered as major risk factors for chronic kidney disease (ckd); moreover, it has a direct effect on developing ckd and end stage renal disease (esrd). here was aimed to examine the association between uncoupling protein 2 (ucp2) gene expression and obesity in ckd patients. methods: ucp2 gene expression was analyzed by real time polymerase chain reaction (rt-pcr) in 93 participants divided into three groups. the groups included 31 non-obese ckd patients, 31 obese ckd patients, and 31 healthy, age-matched, unrelated volunteers as a control group. results: ucp2 gene expression was significantly relevant when comparing the non-obese ckd and obese ckd groups to the control group (p< 0.001). no significant association was found when the groups were compared by gender; chi-square (x2) was 2.38 and p= 0.304. a significant negative correlation was found between ucp2 gene expression and bmi in ckd (p< 0.05). conclusions: these results indicate that ucp2 gene expression plays a significant role as a risk factor for obesity in ckd patients.