lectin-like olr1 3′utr rs1050286 gene polymorphism and plasma oxidized-ldl in coronary artery disease and their relation to cardiovascular risk and outcomes

Background: oxidized low-density lipoprotein (ox-ldl) has an important role in the genesis of coronary atherosclerosis. lectin-like ox-ldl receptor 1 (olr1) contributes to the uptake and internalization of ox- ldl. genetic polymorphisms have been associated with coronary artery disease (cad). here we explore the association of plasma levels of ox-ldl and 3′ utr olr1 (rs1050286) snp with cad risk and inhospital adverse outcomes. methods: a case-control study enrolled 192 patients with st-segment elevation myocardial infarction (stemi), 100 patients with unstable angina, and 100 healthy controls. baseline, clinical characteristics, and risk scores of the patients were determined. plasma ox-ldl and other biochemical variables were measured. all subjects are genotyped for olr1 (rs1050286) by rt-pcr with taqman snp genotyping assay. results: plasma ox-ldl was higher with enhanced sensitivity and specificity in identifying patients with stemi and was found as a significant independent risk factor for cad in those two groups. levels of ox-ldl were increased with increasing poor prognostic factors in stemi patients that are associated with an increased incidence of some adverse events and in-hospital mortality. elevated stemi risk was associated with t allele of olr1 (rs1050286) (odds ratio of 4.9, 95% ci: 2.6-9.4, p< 0.001). stemi patients who have t allele exhibited higher risk scores, coronary multivessel narrowing, and elevated incidence of in-hospital major adverse clinical events. conclusions: these results suggest that plasma ox-ldl, as well as t allele of orl-1 (rs1050286), is associated with the increased risk for developing stemi and the associated adverse clinical outcomes