a genetic variant in proline and serine rich coiled-coil 1 gene is associated with the risk of cardiovascular disease

Background: cardiovascular disease is one of the most common causes of morbidity and mortality worldwide. the proline and serine rich coiled-coil 1 gene in 1p13.3 locus has been reported to be associated with low density lipoprotein cholesterol (ldl-c) and coronary artery disease (cad). the objective of this study was to investigate the association between the rs599839 polymorphism of the proline and serine rich coiled-coil 1 (psrc1) gene with cvd outcomes in a population sample recruited as part of the mashhad-stroke and heart-atherosclerotic-disorders (mashad) cohort. methods: five hundred and nine individuals who had an average follow-up period of 10 years were enrolled as part of the mashad cohort. dna was extracted and genotyped using the taqman-real-time-pcr based method. results: the study found individuals with ga/gg genotypes were at a higher risk of cvds (or= 4.7; 95% ci, 2.5-8.7; p< 0.001) in comparison to those with aa genotype; however, the result was not significant for gg genotype data. conclusions: the results suggest that the ga/gg genotypes of the psrc1gene locus were at increased risk of cvd in a representative population-based cohort, demonstrating further functional analysis to discover the value of emerging marker as a risk stratification biomarker to recognize high risk cases.