clinical significance of circulating serum levels of scd95 and tnf-α in cytoprotection of cervical cancer

Background: this study correlates the serum levels of scd95 & tnf-α with a simple cell-based assay to evaluate the capacity of the serum sample to induce apoptosis in jurkat cells. interlinking of these parameters can be explored to design a minimum invasive diagnostic strategy for cervical cancer (cc). methods: sera samples were assessed to induce apoptosis in jurkat cells through facs. serum levels of scd95 and tnf-α were measured by elisa. jnk phosphorylation was evaluated in sera incubated jurkat cells. data was scrutinized through statistical analysis. results: significantly higher serum levels of scd95 and lower tnf-α levels were observed in cc patients; their sera samples inhibited induction of apoptosis in jurkat cells through reduced jnk phosphorylation. statistical analysis linked these three parameters for the early screening of cc. conclusions: distinct sera levels of scd95 & tnf-α in cc patients showed an anti-apoptotic effect, which can be considered for early detection of cc.