Interferon- Gamma- Inducible Guanosine Triphosphate Cyclohydrolase 1 (GTP-CH1) Pathway Is Associated with Frailty in Egyptian Elderly

Background: chronic low-grade inflammation may be a cardinal pathophysiologic feature in the pathogenesis of frailty. interferon-gamma (inf-γ) is an understudied proinflammatory cytokine in frailty that induces many inflammatory pathways including the guanosine triphosphate cyclohydrolase 1 (gtp-ch1) pathway. our aim was to evaluate the gtp-ch1 pathway in egyptian frail elderly subjects. methods: inf-γ, neopterin, and nitric oxide (no) levels were measured in 80 participants. results: both pre-frail and frail subjects had significantly higher levels of inf-γ, neopterin and lower levels of no than the control group. these biomarkers were associated with the risk of frailty with significant odds ratio. conclusions: elevated inf-γ levels in frail subjects may activate the gtp-ch1 pathway. elevated neopterin and reduced no levels correlated with an active gtp-ch1 pathway. the risk of frailty increased with elevated inf-γ and neopterin and decreased with elevated no levels.