Lack of Association between Interleukin 23R (IL-23R) rs10889677 Polymorphism and Inflammatory Bowel Disease Susceptibility in an Iranian Population

Background: inflammatory bowel diseases (ibds), which include ulcerative colitis (uc) and crohn’s disease (cd), are inflammatory disorders that affect the gastrointestinal tract. a combination of inflammatory cytokines has an important role in ibd development. genome-wide association studies have shown that polymorphisms in the interleukin-23r gene (il-23r) increase susceptibility to ibd. the aim of this study was to investigate the il- 23r 3' utr snp to determine a potential association between genotype distribution and ibd. methods: the case group included 102 ibd patients and the control group included 107 healthy individuals. il-23r polymorphisms rs10889677 were genotyped using pcr-rflp analysis. rflp results were confirmed by direct sequencing. results: the allele and genotype frequencies in patients and controls were evaluated and compared, and no significant association between this functional rs10889677 polymorphism and risk of ibd was observed (p=0.587; adjusted or: 0.89; 95% ci: 0.597-1.339). we also found no significant association between cd (14.71%) and uc (85.29%) patients in allele or genotype levels (p>0.05). conclusions: our results suggest that the rs10889677 a>c polymorphism is not a potential prognostic marker in iranian patients with ibd.