Common Variations in Perilipin rs1052700 and FTO rs3751812 Gene Variants, and Risk for Obesity and Type-2 Diabetes

Background: perilipins are proteins that coat lipid globules in adipocytes, which are steroid-generating cells that play a central role in lipid storage and breakdown. the fto gene is associated with type-2 diabetes (t2d) and increased fat mass. in this work the association of perilipin and fto gene polymorphisms in t2d was investigated. methods: one hundred eighty-three iranian men and women with t2d, and 174 healthy controls with no known metabolic diseases, participated in the study. the subjects were genotyped using tetra-primer amplification refractory mutation system-polymerase chain reaction (tetra-arms-pcr) and their clinical traits were analyzed. results: a significant association was found between the perilipin rs1052700 polymorphism and t2d, and between the fto rs3751812 polymorphism and obesity (p = 0.03 and 0.003, respectively); however, no significant relationship was found between rs3751812 and t2d. conclusions: the fto rs3751812 polymorphism is a major genetic determinant of obesity, but not t2d. the perilipin rs1052700 polymorphism is related to t2d but not obesity.