Are Serum Levels of F2-Isoprostane and Oxidized-LDL Related to Vitamin D Status in Type 2 Diabetic Patients? A Case-Control Study

Background: considerable evidence suggests that oxidative stress affects diabetes mellitus (dm) and contributes to its complications. vitamin d has been shown to possess antioxidant properties. the aim of this study was to determine the association between serum levels of calcifediol (25-oh-d), an indicator of vitamin d status, and lipid profiles with oxidative stress in patients with type 2 diabetes mellitus (t2dm). methods: in this case-control study, 57 t2dm patients with low vitamin d status (< 30 ng/ml) and 48 t2dm patients with normal vitamin d status (> 30 ng/ml) were enrolled. fasting concentrations of 25- oh-d, calcium, phosphorus, parathyroid hormone (pth), lipid profiles, fasting blood sugar (fbs), glycosylated hemoglobin (hba1c), f2-isoprostane, and oxidized-low-density lipoprotein (ox-ldl) were measured. results: the mean fasting serum concentrations of 25-oh-d, calcium, and phosphorus in patients with low vitamin d status were significantly lower than in controls (p < 0.001). the mean concentrations of ox-ldl, f2-isoprostane, total cholesterol, and ldl were significantly higher in patients with low vitamin d status than in controls. there was a negative correlation between vitamin d levels and f2-isoprostane (r = 0.647and p = 0.0001), ldl (r = -0.218 and p = 0.030), and ox-ldl (r = -0.637 and p=0.0001). conclusions: the results of present study indicated that serum concentrations of 25-oh-d were inversely correlated with f2-isoprostane, ldl, and ox-ldl. therefore, vitamin d may have a beneficial effect on the control of lipid profiles and oxidative stress in t2dm patients.